Endocrine Abstracts

Infertility affects 10–15% of couples. In about half of them, a descriptive cause can be established in the male partner, mostly reduced sperm output, of which azoospermia, the complete lack of spermatozoa in the ejaculate, is the most severe form. Non-obstructive azoospermia (NOA) comprises several subforms of spermatogenic failure, such as meiotic arrest (MeiA) and Sertoli-Cell-Only syndrome (SCOS). Most of these phenotypes are suspected to be of genetic origin. However...

Infertility affects 10–15% of couples and the causes of couple infertility are equally attributed to male and female (co-)factors. Male infertility is a genetically and clinically highly heterogeneous disease with a multitude of up to 1,500 genes supposedly involved in spermatogenesis. Thus, unravelling the underlying causes and the pathophysiology is challenging and candidate gene approaches, e.g. picking one or several genes known to cause infertility in mice, did not i...

Background: Recently, a single nucleotide polymorphism (SNP) in the FSHB promoter (−211G>T, rs10835638) was found to be associated with lower serum FSH levels and oligozoospermia in males. In contrast, a SNP in the FSH-receptor gene (FSHR, 2039A>G, rs6166) was previously shown to be associated with FSH levels in women only.Subjects and methods: One thousand two hundred and thirteen male partners in infertile couples without known c...

Aim: To assess the relation between questionnaires of androgenic function (AMS and IIEF-EF scores) and sex hormones (DHT, estradiol and total and free testosterone) in men attending an outpatient clinic for endocrine and reproductive disorders.Methods: We retrospectively reviewed all data entered in the electronic database of the Münster Center of Reproductive Medicine and Andrology (CeRA) Androbase from patients visited between January 2015 and Oct...